Bioactive Small Molecules
Cayman Chemical ANTIBODY Calhex 231 5mg
A negative allosteric modulator of CaSR that blocks calcium-mediated activation (IC50 = 0.39 µM); attenuates the activation of CaSR by calcimimetics
Cayman Chemical ANTIBODY DOBU 1mg
An amphetamine that may act as an antagonist of the 5-HT2 receptor
Medchemexpress LLC 4 5 -Dibromofluores 10mM 1mL | 596-03-2 | 1 ML
4',5'-Dibromofluorescein is a brominated fluorescein derivative used as a fluorescent dye and as a ligand for studying protein properties by spectral analysis. It is supplied as a solid powder and as a ready-to-use 10 mM solution in DMSO for research applications.
- Fluorescent xanthene dye with absorption and emission properties suitable for microscopy and spectral assays.
- CAS 596-03-2; molecular formula C20H10Br2O5; molecular weight 490.10 g·mol⁻¹.
- Dye content/purity typically 95.0% (dye basis).
- Available as a 10 mM solution in DMSO (1 mL) and in solid form in multiple mass quantities.
- Used as a ligand in protein spectral studies, as a staining reagent, and as a fluorescence tracer in analytical applications.
Medchemexpress LLC Avenanthramide A | 299.28 g·mol-1 | C16H13NO5 | 50MG
Avenanthramide A is a phytoalexin which can be found in oats (Avena sativa L ) Avenanthramide A targets the RNA helicase DDX3 leads to mitochondrial swelling and increased ROS production and induces apoptosis in CRC cells Avenanthramide A exhibits antitumor efficacy in mouse model Avenanthramide A orally active[1]
Cayman Chemical RIlmenIdInhemIfumarate 5mg
An antihypertensive agent; binds to imidazole receptors in bovine rostral ventrolateral medulla homogenates (Ki = 6.1 nM); binds α2-adrenergic receptors in bovine prefrontal cortex homogenates (Ki = 87 nM); induces hypotension and bradycardia in anesthetized rats (ED50s = 0.25 and 0.35 mg/kg, respectively); reduces mean arterial pressure and renal sympathetic nerve activity in a rabbit model of renal hypertension induced by a renal artery clip at 2.5 mg/kg; increases levels of LC3-II, a marker of autophagy, in PC12 cells at 1 µM
Cayman Chemical ANTIBODY UPF-1069 1mg
A PARP inhibitor that demonstrates a modest preference for PARP2 over PARP1 (IC50s = 0.3 and 8 µM, respectively)
Cayman Chemical MenaquInon 9 5mg
A vitamin K2 analog; has been found in various bacteria; binds to soluble nitrate reductase; increases plasma prothrombin concentration in vitamin K-deficient rats
Cayman Chemical cIsFlupenthIxolhydrochLRI 5mg
A typical antipsychotic; dopamine D2 receptor antagonist (Ki = 0.38 nM); 5-HT2A inverse agonist (Ki = 7 nM); reduces cocaine-induced locomotor activity and prevents development of conditioned place preferences for the immediate effects of intravenously administered cocaine in rats at 0.5 mg/kg; inhibits acid sphingomyelinase activity by 81.8% at 10 mM
Cayman Chemical ANTIBODY DOPAL 50mg
An aldehyde product of the oxidative deamination of dopamine that is toxic to neurons
Cayman Chemical ANTIBODY FIlgotInIb 25mg
A JAK1 inhibitor (IC50 = 10 nM); selective for JAK1 over JAK3 (IC50 = 810 nM) but also inhibits JAK2 and Tyk2 (IC50s = 28 and 116 nM, respectively), as well as Abl, FLT1, -3 and -4, FMS, Mer, and TBK1 activity by >35% in a panel of 177 tyrosine kinases at 1 µM; inhibits IL-6-induced phosphorylation of STAT1 in CD4+ T cells (IC50 = 629 nM in isolated human whole blood); reduces hind paw macrophage and T cell infiltration and bone erosion in a rat model of collagen-induced arthritis at 0.1-30 mg/kg per day for 15 days
Selleck Chemical LLC Culmerciclib E4703-5MG
Culmerciclib (TQB3616) is a potent inhibitor of cyclin dependent kinase (CDK)4/6 and exhibits highly effective antineoplastic activity TQB3616 exhibits significant synergistic antitumor activity in estrogen receptor (ER)-positive/HER2-negative or HER2-positive breast cancer when combined with endocrine therapy or Human Epidermal Growth Factor Receptor 2 (HER2) targeted therapy
Medchemexpress LLC AMP-Deoxynojirimycin 5mg | 216758-20-2 | 5 MG
AMP-Deoxynojirimycin (AMP-DNM) is a research-grade small molecule inhibitor of ceramide glucosyltransferase and non-lysosomal glucocerebrosidase (GBA2). It reduces glucosylceramide (GlcCer) biosynthesis and is used in cellular and animal studies to probe glycosphingolipid metabolism, inflammation, and metabolic disease. Supplied as a solid for research use only.
- Inhibits ceramide glucosyltransferase and GCase2.
- Reduces glucosylceramide (GlcCer) biosynthesis.
- Used in cellular and animal models to study glycosphingolipid metabolism and inflammation.
- CAS number 216758-20-2; molecular formula C22H39NO5; molecular weight 397.55 g/mol.
- Batch purities reported up to 99.7% (HPLC), depending on lot.
- For research use only; not for human or clinical use.
Medchemexpress LLC EXP3179 10mM 1mL | 114798-36-6 | 420.89 | C22H21ClN6O | 1 ML
EXP3179 is an important intermediate aldehyde metabolite of Losartan EXP3179 has no AT1-R blocking activity but potently inhibits the expression of endothelial cyclooxygenase (COX)-2 EXP3179 exerts potent anti-inflammatory actions[1]
Perkin Elmer US LLC 19 ga. Custodion CME Sampling Device with 3 Replacement Coils
Sampling just got easier - Simplify your collection devices to save time obtaining field samples by investing in CME technology. CME is ideal for liquids including explosives, accelerants, drugs of abuse and, semi-volatiles. This novel technique consisting of a finely coiled wire that traps liquid samples by capillary action. When used with the Torion T-9 Portable GC/MS, in-field sample analysis is quick, easy, and reliable.